Extraordinary extended lampbrush chromosomes with thousands of transcription loops are favorable objects in chromosome biology. Chromosomes become lampbrushy due to unusually high rate of transcription during oogenesis. However, until recently, the information on the spectrum of transcribed sequences as well as genomic context of individual chromomeres was mainly limited to tandemly repetitive elements. Here we briefly outline novel findings and future directions in lampbrush chromosome studies in the post‐genomic era. We emphasize the fruitfulness of combining genome‐wide approaches with microscopy imaging (...) techniques using lampbrush chromosomes as a remarkable model object. We believe that new data on the spectrum of sequences transcribed on the lateral loops of lampbrush chromosomes and their structural organization push the boundaries in the discussion of their biological role. Also see the video abstract here: https://youtu.be/zexoHfzX9rM. (shrink)

In this paper, we focus on the launch of the Great Soviet Encyclopedia, which was first published in 1925. We present the context of the launch and explain why it was closely connected to the period of the New Economic Policy. In the last section, we examine four articles about randomness and probability included in the first volumes of the encyclopedia in order to illustrate some debates from within the scientific scene in the USSR during the 1920s.